首页 > 试剂耗材 > Gadospin D MRI 动态增强造影剂

Gadospin D球状结构中包含24个钆离子。Gadospin TM D是一款独一无二的可实现MRI对血管完整性、血管生成以及炎症组织动态对比增强(DCE)的造影剂。

Gadospin D.pngGadospin D 1.png 

(左图)Gadospin D的 DEC-MRI肿瘤治疗监测。小鼠肿瘤抗血管研究,针对肿瘤区域内血管对造影剂的摄取分析。T1加权成像可以明显看到治疗组中肿瘤血管对造影剂的吸收明显低于对照组,原因可以归结于药物对新生血管的抑制效果。


参考文献

1. Su, M. Y.et al. (2002) Measurement of volumetric and vascular changes with dynamic contrast enhanced MRI for cancer therapy monitoring. Technol. Cancer Res. Treat. 1:479-488.

2. Verhoye, M. et al. (2002) Assessment of the neovascular permeability in glioma xenografts by dynamicT(1) MRI with Gadomer-17. Magn. Reson. Med 47:305-313.

3. Fink, C. et al. (2003) High-resolution three-dimensional MR angiography of rodent tumors: morphologic characterization of intratumoral vasculature. J. Magn. Reson. Imaging 18:59-65.

4. Hamzah, J. et al. (2008) Vascular normalization in Rgs5-deficient tumours promotes immune destruction. Nature 453:410-414.


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