United Well team uses radionuclide labeled molecular imaging probe to evaluate the in vivo and in vitro performance of radio-labeled (matched) substances, including in vivo imaging, to screen out radiopharmaceuticals with potential application value.
United Well has extensive professional knowledge in pharmacodynamics research. The research on non-clinical pharmacodynamics of radiopharmaceuticals in the laboratory includes, but not limited to: evaluating the effects of radiopharmaceuticals and the non-radioactive components with binding ability to the target on the functional activity of the target; evaluating the effects of radiopharmaceuticals on other receptors, enzymes, ion channels, transporters, etc., and analyzing the potential off-target effects.
Pharmacokinetic study/toxicokinetic study
This study provides our laboratory staff with vital research information such as absorption, distribution, metabolism, excretion and other pharmacokinetics of radiopharmaceuticals. When radiopharmaceuticals do not undergo radioactive dissociation in vivo, the biological distribution data and blood concentration data at different time points of radiopharmaceuticals can reflect the systematic exposure, exposure in target organs/non-target organs and elimination characteristics of radiopharmaceuticals.
Biodistribution of radioactivity in vivo
Concentration-time curve study of blood radioactivity
Radioactive excretion test
Balance of radioactive material
In vivo biotransformation assays