Eckert & Ziegler (ISIN DE0005659700, SDAX) and PharmaLogic Holdings Corp. ("PharmaLogic") have signed a reservation agreement for the supply of the therapeutic radioisotope Actinium-225 (Ac-225). Under the terms of the agreement, PharmaLogic will have access to Eckert & Ziegler's high-purity, non-carrier-added Actinium-225 for the labeling of radiopharmaceuticals for research and development work and commercial use.
Actinium-225 is used as an active substance in cancer treatment. The radioisotope emits powerful, high-energy alpha particles with short penetration depths, enabling precise treatment of tumor cells, including elusive micro-metastases, with minimal impact on surrounding healthy tissue. Clinical and market experts expect the demand of Actinium-225 to increase significantly over the next decade.
"The supply of Actinium-225 has been limited for years, slowing both clinical research activities and commercial use," stated Dr. Harald Hasselmann, CEO of Eckert & Ziegler. "We have taken steps to improve this with the establishment of our own Ac-225 production facilities and are pleased to now support PharmaLogic's activities to expand the use of Ac-225 based radiopharmaceuticals."
"Consistent with our mission to bring transformative radiopharmaceuticals to patients, increased access to key radioisotope Ac-225 is crucial for our organization and pharmaceutical partners," explained Steve Chilinski, CEO of PharmaLogic. "Our agreement with Eckert & Ziegler will ensure our programs can progress efficiently and enable patient access to the latest therapies."
Eckert & Ziegler will establish GMP-compliant production of larger quantities of Ac-225 in 2024. Subsequently, the submission of a Drug Master File to the United States Food & Drug Administration is planned.
About Eckert & Ziegler.
Eckert & Ziegler Strahlen- und Medizintechnik AG with more than 1.000 employees is a leading specialist for isotope-related components in nuclear medicine and radiation therapy. The company offers a broad range of services and products for the radiopharmaceutical industry, from early development work to contract manufacturing and distribution. Eckert & Ziegler shares (ISIN DE0005659700) are listed in the SDAX index of Deutsche Börse.
