CR 35 Bio is a high-speed isotope scanner suitable for all types of imaging plates/storage screens below 35x43cm. It can be used for various nuclides, such as 3H, 11C, 14C, 18F, 32P, 33P, 35S,59Fe, 68Ga, 99mTc, 111In, 125I, 131I, 137Cs , etc.
CR-35 Bio can perform filmless autoradiography of tissue slices, using radiation emitted by radionuclides to sensitize silver halide in latex to form a latent image, which is developed and fixed to finally form an image, and through image analysis, the distribution location and quantity of radioactive tracers can be accurately determined. This more efficient autoradiography method can replace the traditional film, with the spatial resolution increased to 12.5μm, and the imaging speed increased to 100 times that of film.
The novel design concept ensures the high-speed scanning, high sensitivity, high imaging speed and high resolution of the system while the body is small. The imaging plate can be reused, and the built-in imaging plate erasing unit can read and erase the imaging plate in one step. The signals collected are focused on 30μm by laser, allowing 30 to 200μm pixel laser beams to scan, and then detected and imaged by its optical system, and created a high-resolution digital image with quantitative data in the form of an image file.
Features:
● Easy and simple usage
● High-speed scanning
● Integrated imaging plate eraser
● Whole body autoradiography and quantification
● 16-bit dynamic range
● The 635nm red laser is focused on 30μm m.
● Low noise operation
Autoradiography images of MDA-MB-231 tumor cells incubated with 68GA-Trap -(RGD)3;
Figure A: Non-blocking with α v3-integrin receptor;
Figure B: Blocking with α v3-integrin receptor.
(Figure C and Figure D): Fluorescent scanning imaging after specific immunofluorescence staining of αvß3 integrin receptor sectioned at the same site as A/B.
SI = signal intensity, a.u. = arbitrary units.
SI = signal intensity, a.u. = arbitrary units.
