Like blood vessels, lymph is distributed throughout the body, while lymphoma is a malignant tumor formed by the mutation of lymphocytes, and it is also one of the highest incidence of malignant tumors in the world in recent years. According to the data, a new lymphoma patient is diagnosed every 9 minutes in the world, with an annual increase of 7.5%, which is the highest incidence in blood tumors.
CD20 is a transmembrane protein and also a marker of B cells. CD20 guides the B cell growth and differentiation into plasma cells. Its overexpression on the tumor-induced B cell surface makes it an ideal and specific therapeutic target for the immunotherapy of B cell malignancies. Bispecific antibodies can simultaneously and specifically bind both antigens or the epitope antigens of both antibody molecules. Compared with common antibodies, bispecific antibodies (BsAb) are more specific.
We are using 89Zr-labeled UW07 to optimize the safety and effective dose of UW07 by positron emission tomography (PET) imaging.By labeling with 89Zr, we are evaluating the PK, safety, and targeting effects of UW07 in humanized transgenic animal models, as well as dose-escalation dynamic PET imaging. At the same time, we are also conducting a preclinical α-PRIT treatment study of BSAB-U07.